Nieto-Castanon, A. (2020). General Linear Model. In Handbook of functional connectivity Magnetic Resonance Imaging methods in CONN (pp. 6382). Hilbert Press.

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General Linear Model

Nieto-Castanon, A. (2020)


Second-level analyses allow researchers to make inferences about properties of groups or populations, by generalizing from the observations of only a subset of subjects in a study. This chapter describes the mathematics behind the General Linear Model (GLM), the approach used in CONN for all second-level analyses of functional connectivity measures. The description includes GLM model definition, parameter estimation, and hypothesis testing framework, as well as several practical examples and general guidelines aimed at helping researchers use this method to answer their specific research questions.